Javier DeFelipe
- Published in print:
- 2009
- Published Online:
- January 2010
- ISBN:
- 9780195392708
- eISBN:
- 9780199863525
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195392708.001.0001
- Subject:
- Neuroscience, History of Neuroscience, Molecular and Cellular Systems
This book contains a large collection of beautiful figures produced throughout the 19th and beginning of the 20th century, which represent some characteristic examples of the early days of research ...
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This book contains a large collection of beautiful figures produced throughout the 19th and beginning of the 20th century, which represent some characteristic examples of the early days of research in neuroscience. The main aim of this work is to demonstrate to the general public that the study of the nervous system is not only important for the many obvious reasons related to brain function in both health and disease, but also for the unexpected natural beauty that it beholds. This beauty has been discovered thanks to the techniques used to visualize the microscopic structure of the brain, a true forest of colorful and florid neural cells. As illustrated by his marvelous drawings, the studies of Santiago Ramón y Cajal (1852-1934) no doubt contributed more than those of any other researcher at the time to the growth of modern neuroscience. Thus, his name has been honored in the title of this book, even though the figures contained in the main body of it are from 91 different authors. Looking at the illustrations in this book, the readers will find that many of the early researchers that studied the nervous system were also true artists, of considerable talent and esthetic sensibility. Hence, the present book contains numerous drawings of some of the most important pioneers in neuroscience, including Deiters, Kolliker, Meynert, Ranvier, Golgi, Retzius, Nissl, Dogiel, Alzheimer, del Rio-Hortega, and de Castro.Less
This book contains a large collection of beautiful figures produced throughout the 19th and beginning of the 20th century, which represent some characteristic examples of the early days of research in neuroscience. The main aim of this work is to demonstrate to the general public that the study of the nervous system is not only important for the many obvious reasons related to brain function in both health and disease, but also for the unexpected natural beauty that it beholds. This beauty has been discovered thanks to the techniques used to visualize the microscopic structure of the brain, a true forest of colorful and florid neural cells. As illustrated by his marvelous drawings, the studies of Santiago Ramón y Cajal (1852-1934) no doubt contributed more than those of any other researcher at the time to the growth of modern neuroscience. Thus, his name has been honored in the title of this book, even though the figures contained in the main body of it are from 91 different authors. Looking at the illustrations in this book, the readers will find that many of the early researchers that studied the nervous system were also true artists, of considerable talent and esthetic sensibility. Hence, the present book contains numerous drawings of some of the most important pioneers in neuroscience, including Deiters, Kolliker, Meynert, Ranvier, Golgi, Retzius, Nissl, Dogiel, Alzheimer, del Rio-Hortega, and de Castro.
Edmund T. Rolls
- Published in print:
- 2016
- Published Online:
- November 2016
- ISBN:
- 9780198784852
- eISBN:
- 9780191836299
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198784852.001.0001
- Subject:
- Neuroscience, Molecular and Cellular Systems, Behavioral Neuroscience
The aim of this book is to provide insight into the principles of operation of the cerebral cortex. These principles are key to understanding how we, as humans, function. There have been few previous ...
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The aim of this book is to provide insight into the principles of operation of the cerebral cortex. These principles are key to understanding how we, as humans, function. There have been few previous attempts to set out some of the important principles of operation of the cortex, and this book is pioneering. The book goes beyond separate connectional neuroanatomical, neurophysiological, neuroimaging, neuropsychiatric, and computational neuroscience approaches, by combining evidence from all these areas to formulate hypotheses about how and what the cerebral cortex computes. As clear hypotheses are needed in this most important area of 21st century science, how our brains work, I have formulated a set of hypotheses about the principles of cortical operation to guide thinking and future research. The book focusses on the principles of operation of the cerebral cortex, because at this time it is possible to propose and describe many principles, and many are likely to stand the test of time, and provide a foundation for further developments, even if some need to be changed. In this context, I have not attempted to produce an overall theory of operation of the cerebral cortex, because at this stage of our understanding, such a theory would be incorrect or incomplete. However, many of the principles described will provide the foundations for more complete theories of the operation of the cerebral cortex. This book is intended to provide a foundation for future understanding, and it is hoped that future work will develop and add to these principles of operation of the cerebral cortex. The book includes Appendices on the operation of many of the neuronal networks described in the book, together with simulation software written in Matlab.Less
The aim of this book is to provide insight into the principles of operation of the cerebral cortex. These principles are key to understanding how we, as humans, function. There have been few previous attempts to set out some of the important principles of operation of the cortex, and this book is pioneering. The book goes beyond separate connectional neuroanatomical, neurophysiological, neuroimaging, neuropsychiatric, and computational neuroscience approaches, by combining evidence from all these areas to formulate hypotheses about how and what the cerebral cortex computes. As clear hypotheses are needed in this most important area of 21st century science, how our brains work, I have formulated a set of hypotheses about the principles of cortical operation to guide thinking and future research. The book focusses on the principles of operation of the cerebral cortex, because at this time it is possible to propose and describe many principles, and many are likely to stand the test of time, and provide a foundation for further developments, even if some need to be changed. In this context, I have not attempted to produce an overall theory of operation of the cerebral cortex, because at this stage of our understanding, such a theory would be incorrect or incomplete. However, many of the principles described will provide the foundations for more complete theories of the operation of the cerebral cortex. This book is intended to provide a foundation for future understanding, and it is hoped that future work will develop and add to these principles of operation of the cerebral cortex. The book includes Appendices on the operation of many of the neuronal networks described in the book, together with simulation software written in Matlab.
Howard Eichenbaum
- Published in print:
- 2011
- Published Online:
- May 2012
- ISBN:
- 9780199778614
- eISBN:
- 9780199932962
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780199778614.001.0001
- Subject:
- Neuroscience, Behavioral Neuroscience, Molecular and Cellular Systems
This book introduces the brain's remarkable capacity for memory. Like the first edition, this updated second edition begins with a history of memory research, starting with a ‘Golden Era’ at the turn ...
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This book introduces the brain's remarkable capacity for memory. Like the first edition, this updated second edition begins with a history of memory research, starting with a ‘Golden Era’ at the turn of the 20th century, and progressing to our current understanding of the neurobiology of memory. Subsequent sections of the book discuss the cellular basis of memory, amnesia in humans and animals, the physiology of memory; declarative, procedural, and emotional memory systems; memory consolidation, and the control of memory by the prefrontal cortex. The book is organized into four sections, which highlight the major themes of the text. The first theme is connection, which considers how memory is fundamentally based on alterations in the connectivity of neurons. The first section of the book covers the most well studied models of cellular mechanisms of neural plasticity that may underlie memory. The second theme is cognition, which involves fundamental issues in the psychological structure of memory. This next section of the book considers the competition among views on the nature of cognitive processes that underlie memory, and tells how the controversy was eventually resolved. The third theme is compartmentalization, which is akin to the classic problem of memory localization. However, unlike localization, the notion of ‘compartments’ is intended to avoid the notion that particular memories are pigeon-holed into specific loci, and instead emphasize that different forms of memory are accomplished by distinct modules or brain systems. This third section of the book surveys the evidence for multiple memory systems, and outlines how they are mediated by different brain structures and systems. The fourth and final theme is consolidation, the process by which memories are transformed from a labile trace into a permanent store.Less
This book introduces the brain's remarkable capacity for memory. Like the first edition, this updated second edition begins with a history of memory research, starting with a ‘Golden Era’ at the turn of the 20th century, and progressing to our current understanding of the neurobiology of memory. Subsequent sections of the book discuss the cellular basis of memory, amnesia in humans and animals, the physiology of memory; declarative, procedural, and emotional memory systems; memory consolidation, and the control of memory by the prefrontal cortex. The book is organized into four sections, which highlight the major themes of the text. The first theme is connection, which considers how memory is fundamentally based on alterations in the connectivity of neurons. The first section of the book covers the most well studied models of cellular mechanisms of neural plasticity that may underlie memory. The second theme is cognition, which involves fundamental issues in the psychological structure of memory. This next section of the book considers the competition among views on the nature of cognitive processes that underlie memory, and tells how the controversy was eventually resolved. The third theme is compartmentalization, which is akin to the classic problem of memory localization. However, unlike localization, the notion of ‘compartments’ is intended to avoid the notion that particular memories are pigeon-holed into specific loci, and instead emphasize that different forms of memory are accomplished by distinct modules or brain systems. This third section of the book surveys the evidence for multiple memory systems, and outlines how they are mediated by different brain structures and systems. The fourth and final theme is consolidation, the process by which memories are transformed from a labile trace into a permanent store.
Howard Eichenbaum
- Published in print:
- 2002
- Published Online:
- May 2009
- ISBN:
- 9780195141740
- eISBN:
- 9780199865741
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195141740.001.0001
- Subject:
- Neuroscience, Behavioral Neuroscience, Molecular and Cellular Systems
This book details the brain's remarkable capacity for memory. The book is organized into sections corresponding to its four major themes: Connection considers how memory is based on alterations to ...
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This book details the brain's remarkable capacity for memory. The book is organized into sections corresponding to its four major themes: Connection considers how memory is based on alterations to the communication between nerve cells. Cognition discusses the fundamental psychological structure of memory. Compartmentalization involved the notion that the different forms of memory are accomplished by distinct brain systems. Consolidation refers to processes by which memories are transformed from a labile trace into a permanent store. The book provides insights into how memory works and how it is fundamental to all aspects of cognition, behavior, and emotion.Less
This book details the brain's remarkable capacity for memory. The book is organized into sections corresponding to its four major themes: Connection considers how memory is based on alterations to the communication between nerve cells. Cognition discusses the fundamental psychological structure of memory. Compartmentalization involved the notion that the different forms of memory are accomplished by distinct brain systems. Consolidation refers to processes by which memories are transformed from a labile trace into a permanent store. The book provides insights into how memory works and how it is fundamental to all aspects of cognition, behavior, and emotion.
Joaquín M. Fuster
- Published in print:
- 2005
- Published Online:
- January 2010
- ISBN:
- 9780195300840
- eISBN:
- 9780199863655
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195300840.001.0001
- Subject:
- Neuroscience, Molecular and Cellular Systems
This book explores whether the mental order corresponds to the order of structures, events, and processes in one part of the neural order, namely, the cerebral cortex. For clarity and simplicity, ...
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This book explores whether the mental order corresponds to the order of structures, events, and processes in one part of the neural order, namely, the cerebral cortex. For clarity and simplicity, this means the search for a spatial and temporal order in the cerebral cortex that matches the cognitive order in every respect. A change or difference in the cortical order corresponds to a change or difference in the mental order. The principal aim of this book is to map cognitive networks onto cortical networks. It has implications for cognitive neuroscience, neurophysiology, neurobiology, neuroimaging, neurology, neurosurgery, psychiatry, cognitive psychology, and linguistics. The book will also interest students in all the disciplines of neuroscience and can be used as a text or collateral reading in courses on systems neuroscience, behavioral neuroscience, cognitive science, network modeling, physiological psychology, and linguistics.Less
This book explores whether the mental order corresponds to the order of structures, events, and processes in one part of the neural order, namely, the cerebral cortex. For clarity and simplicity, this means the search for a spatial and temporal order in the cerebral cortex that matches the cognitive order in every respect. A change or difference in the cortical order corresponds to a change or difference in the mental order. The principal aim of this book is to map cognitive networks onto cortical networks. It has implications for cognitive neuroscience, neurophysiology, neurobiology, neuroimaging, neurology, neurosurgery, psychiatry, cognitive psychology, and linguistics. The book will also interest students in all the disciplines of neuroscience and can be used as a text or collateral reading in courses on systems neuroscience, behavioral neuroscience, cognitive science, network modeling, physiological psychology, and linguistics.
O. D. Creutzfeldt
- Published in print:
- 1995
- Published Online:
- March 2012
- ISBN:
- 9780198523246
- eISBN:
- 9780191724510
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198523246.001.0001
- Subject:
- Neuroscience, Molecular and Cellular Systems
The cortex continues to be the subject of intense scientific curiosity, as it has been for the past thirty years. It is the most highly developed part of the brain, yet the youngest in evolutionary ...
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The cortex continues to be the subject of intense scientific curiosity, as it has been for the past thirty years. It is the most highly developed part of the brain, yet the youngest in evolutionary terms. It is fundamental to human behaviour, thinking, and self-understanding, and a study of its structure and performance must encompass aspects of anatomy, physiology, psychology, and neurology. This book provides an account of the structural and functional organisation of the cerebral cortex from the point of view of one of the pioneers in the field. It is a revised and updated translation of the original German text, and brings together the biological, psychological, and philosophical strands of enquiry relating to this area of the brain.Less
The cortex continues to be the subject of intense scientific curiosity, as it has been for the past thirty years. It is the most highly developed part of the brain, yet the youngest in evolutionary terms. It is fundamental to human behaviour, thinking, and self-understanding, and a study of its structure and performance must encompass aspects of anatomy, physiology, psychology, and neurology. This book provides an account of the structural and functional organisation of the cerebral cortex from the point of view of one of the pioneers in the field. It is a revised and updated translation of the original German text, and brings together the biological, psychological, and philosophical strands of enquiry relating to this area of the brain.
Michael J. Gutnick and Istvan Mody (eds)
- Published in print:
- 1995
- Published Online:
- March 2012
- ISBN:
- 9780195083309
- eISBN:
- 9780199847464
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195083309.001.0001
- Subject:
- Neuroscience, Molecular and Cellular Systems
Looking beyond the classical “wiring-diagram” description of the organization of cortical cells into circuits, this book focuses on dynamic aspects of cerebral cortical physiology, both at the ...
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Looking beyond the classical “wiring-diagram” description of the organization of cortical cells into circuits, this book focuses on dynamic aspects of cerebral cortical physiology, both at the single-neuron and network levels. Recent years have seen a remarkable expansion of knowledge about the basic cellular physiology and molecular biology of cortical nerve cells—their membrane properties, their synaptic characteristics, their functional connectivity, their development, and the mechanisms of their response to injury. This book includes contributions by many of the neurobiologists and neurologists directly responsible for these advances. The four main sections of the book are: Cortical Neurons and Synapses, The Cortical Network, The Developing Cortical Neuron, and The Vulnerable Cortical Neuron. This is a balanced multidisciplinary perspective on the normal and pathological function of the cells of the cerebral cortex, identifying the controversies and critical issues facing modern researchers in this field.Less
Looking beyond the classical “wiring-diagram” description of the organization of cortical cells into circuits, this book focuses on dynamic aspects of cerebral cortical physiology, both at the single-neuron and network levels. Recent years have seen a remarkable expansion of knowledge about the basic cellular physiology and molecular biology of cortical nerve cells—their membrane properties, their synaptic characteristics, their functional connectivity, their development, and the mechanisms of their response to injury. This book includes contributions by many of the neurobiologists and neurologists directly responsible for these advances. The four main sections of the book are: Cortical Neurons and Synapses, The Cortical Network, The Developing Cortical Neuron, and The Vulnerable Cortical Neuron. This is a balanced multidisciplinary perspective on the normal and pathological function of the cells of the cerebral cortex, identifying the controversies and critical issues facing modern researchers in this field.
Roger Traub, MD and Miles Whittington, PhD
- Published in print:
- 2010
- Published Online:
- May 2010
- ISBN:
- 9780195342796
- eISBN:
- 9780199776276
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780195342796.001.0001
- Subject:
- Neuroscience, Molecular and Cellular Systems, Development
This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions ...
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This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions between neurons – mediated by both chemical synapses and by gap junctions – can lead to oscillations in populations of cells. The discussion is based largely on data derived from in vitro systems (hippocampus, cerebral and cerebellar cortex) and from network modeling. Finally, the book considers how brain oscillations can provide insight into normal brain function as well as pathophysiology.Less
This book reviews a number of clinical neuropsychiatric conditions in which brain oscillations play an essential role. It discusses how the intrinsic properties of neurons, and the interactions between neurons – mediated by both chemical synapses and by gap junctions – can lead to oscillations in populations of cells. The discussion is based largely on data derived from in vitro systems (hippocampus, cerebral and cerebellar cortex) and from network modeling. Finally, the book considers how brain oscillations can provide insight into normal brain function as well as pathophysiology.
Jay Schulkin
- Published in print:
- 2017
- Published Online:
- June 2017
- ISBN:
- 9780198793694
- eISBN:
- 9780191835506
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198793694.001.0001
- Subject:
- Neuroscience, Molecular and Cellular Systems, Behavioral Neuroscience
This book discusses just how diverse a peptide corticotrophin-releasing factor (CRF) is, as demonstrated by its presence in various tissues in the body, including the skin, the placenta, and various ...
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This book discusses just how diverse a peptide corticotrophin-releasing factor (CRF) is, as demonstrated by its presence in various tissues in the body, including the skin, the placenta, and various regions of the brain. As Dobzhansky (1962) noted, in light of Darwin (1874), and beyond, CRF must be placed in the larger world of regulatory biology. Evolutionary trends do not proceed in a continuous one-dimensional direction; there are starts, turns, and abrupt ends. The study of CRF is mostly about diverse functions in physiological and behavioral regulation of the internal milieu and adapting to an ecological and or social context. The book begins with a depiction of the evolutionary origins of CRF in living things, dating back hundreds of millions of years. The book pushes the conception of CRF beyond the HPA axis and common knowledge. We study the role of CRF in metamorphosis and parturition. Further, CRF is a contributor to fear and anxiety, and the book explains how excessive fear is tied to anxiety disorders and vulnerability to the breakdown of mental and physical health. Also discussed is CRF in approach/avoidance behaviors across pre- and postnatal events. CRF is intimately involved in organ development, but it is also linked to devolution of function and conditions of danger. Cravings, addictions, and how CRF is tied both to the ingestion of diverse drugs and to withdrawal are explored. CRF is considered as an epistemic object, addressing what constitutes an information molecule, in general, and CRF, in particular.Less
This book discusses just how diverse a peptide corticotrophin-releasing factor (CRF) is, as demonstrated by its presence in various tissues in the body, including the skin, the placenta, and various regions of the brain. As Dobzhansky (1962) noted, in light of Darwin (1874), and beyond, CRF must be placed in the larger world of regulatory biology. Evolutionary trends do not proceed in a continuous one-dimensional direction; there are starts, turns, and abrupt ends. The study of CRF is mostly about diverse functions in physiological and behavioral regulation of the internal milieu and adapting to an ecological and or social context. The book begins with a depiction of the evolutionary origins of CRF in living things, dating back hundreds of millions of years. The book pushes the conception of CRF beyond the HPA axis and common knowledge. We study the role of CRF in metamorphosis and parturition. Further, CRF is a contributor to fear and anxiety, and the book explains how excessive fear is tied to anxiety disorders and vulnerability to the breakdown of mental and physical health. Also discussed is CRF in approach/avoidance behaviors across pre- and postnatal events. CRF is intimately involved in organ development, but it is also linked to devolution of function and conditions of danger. Cravings, addictions, and how CRF is tied both to the ingestion of diverse drugs and to withdrawal are explored. CRF is considered as an epistemic object, addressing what constitutes an information molecule, in general, and CRF, in particular.
Greg Stuart, Nelson Spruston, and Michael Häusser (eds)
- Published in print:
- 2016
- Published Online:
- May 2016
- ISBN:
- 9780198745273
- eISBN:
- 9780191819735
- Item type:
- book
- Publisher:
- Oxford University Press
- DOI:
- 10.1093/acprof:oso/9780198745273.001.0001
- Subject:
- Neuroscience, Sensory and Motor Systems, Molecular and Cellular Systems
Dendrites are complex neuronal structures that receive and integrate synaptic input from other nerve cells. They therefore play a critical role in brain function. Although dendrites were discovered ...
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Dendrites are complex neuronal structures that receive and integrate synaptic input from other nerve cells. They therefore play a critical role in brain function. Although dendrites were discovered over a century ago, due to the development of powerful new techniques there has been a dramatic resurgence of interest in the properties and function of these beautiful structures. This is the first book to be devoted exclusively to dendrites. It contains a comprehensive survey of the current state of dendritic research across a wide range of topics, from dendritic morphology, evolution, development, and plasticity through to the electrical, biochemical, and computational properties of dendrites, and finally to the key role of dendrites in brain disease. The third edition has been thoroughly revised, with each chapter updated or completely rewritten by leading experts, plus the addition of a number of new chapters. “Dendrites” should be of interest to researchers and students in neuroscience and related fields, as well as to anyone interested in how the brain works.Less
Dendrites are complex neuronal structures that receive and integrate synaptic input from other nerve cells. They therefore play a critical role in brain function. Although dendrites were discovered over a century ago, due to the development of powerful new techniques there has been a dramatic resurgence of interest in the properties and function of these beautiful structures. This is the first book to be devoted exclusively to dendrites. It contains a comprehensive survey of the current state of dendritic research across a wide range of topics, from dendritic morphology, evolution, development, and plasticity through to the electrical, biochemical, and computational properties of dendrites, and finally to the key role of dendrites in brain disease. The third edition has been thoroughly revised, with each chapter updated or completely rewritten by leading experts, plus the addition of a number of new chapters. “Dendrites” should be of interest to researchers and students in neuroscience and related fields, as well as to anyone interested in how the brain works.
“A Gentleman and an Officer”
‘A Nation of Beggars’?
The A Priori in Philosophy
A. J. Appasamy and his Reading of Rāmānuja
A. J. Tomlinson
Aaron Hill
The Abbey Theatre, 1899-1999
The Abbots and Priors of Late Medieval and Reformation England
Abelard and Heloise
