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Neuroglycobiology
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Neuroglycobiology: (Molecular and Cellular Neurobiology)

Minoru Fukuda, Urs Rutishauser, and Ronald L. Schnaar

Abstract

In the past decade, there have been tremendous developments in the understanding of the structure, biosynthesis, and function of glycoconjugates present in the nervous system. These developments were initiated by advances in the molecular cloning of glycosyltransferases that direct the synthesis of these complex carbohydrates. In particular, the molecular cloning of polysialyltransferases, HNK-1 sulfotransferase, ganglioside sialyltransferases, and proteoglycan sulfotransferases provided a great opportunity to determine the roles of these glycans in the nervous system. Moreover, the availabili ... More

Keywords: glycoconjugates, nervous system, molecular cloning, glycosyltransferases, polysialyltransferases, HNK-1 glycans, brain glycolipids, biosynthetic pathway, gene knockout mice, metabolism

Bibliographic Information

Print publication date: 2005 Print ISBN-13: 9780198525387
Published to Oxford Scholarship Online: September 2009 DOI:10.1093/acprof:oso/9780198525387.001.0001

Authors

Affiliations are at time of print publication.

Minoru Fukuda, editor
Glycobiology Program, Cancer Research Center, The Burnham Institute, La Jolla, USA

Urs Rutishauser, editor
Department of Cellular Biochemistry & Biophysics, Memorial Sloan-Kettering Cancer Center, New York, USA

Ronald L. Schnaar, editor
Departments of Pharmacology and Neuroscience, Johns Hopkins School of Medicine, Baltimore USA