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AlcoholScience, Policy and Public Health$
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Peter Boyle, Paolo Boffetta, Albert B. Lowenfels, Harry Burns, Otis Brawley, Witold Zatonski, and Jürgen Rehm

Print publication date: 2013

Print ISBN-13: 9780199655786

Published to Oxford Scholarship Online: May 2013

DOI: 10.1093/acprof:oso/9780199655786.001.0001

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Alcohol metabolism and genetic control

Alcohol metabolism and genetic control

Chapter:
(p.57) Chapter 8 Alcohol metabolism and genetic control
Source:
Alcohol
Author(s):

Philip J. Brooks

Samir Zakhari

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199655786.003.0008

Alcohol metabolism plays a key role in the biological and toxic effects of alcohol consumption on the human body. This chapter discusses the main pathways of alcohol metabolism and the role of genetics in modulating alcohol metabolism. The three main enzymes that carry out alcohol oxidation are alcohol dehydrogenase, cytochrome P450 2E1, and, to a lesser extent, catalase, all of which generate acetaldehyde. In addition to these three enzymes, the importance of microbial alcohol metabolism is also discussed, as the production of acetaldehyde by microbes in human gastrointestinal tract plays an important role in alcohol-related carcinogenesis.

Keywords:   alcohol use, alcohol consumption, toxic effects, genetics, are alcohol dehydrogenase, cytochrome P450 2E1, catalase, acetaldehyde

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